Nanoporous Microspheres for Advanced Separations
Research efforts have long been directed toward the development of new, high-resolution and ultra-sensitive bioanalytical separation techniques. Via aerosol-assisted self-assembly, we have achieved macroporous microspheres that maintain a high surface area which is ideal for chromatographic separations of complex biological mixtures.
In collaboration with the Novotny Laboratory (Indiana University), we are currently evaluating our platform for lectin affinity enrichment of glycoproteins, as altered glycosylation is linked to cancer, inflammatory, and degenerative diseases.
Funding provided by NIH R01-GM for "Sensitive Methods for Glycoconjugate Analysis" Co-Investigator (PI: Milos Novotny-Chemistry, Indiana University) and previously by Indiana CTSI - Research Invention and Scientific Commercialization (RISC) Program for "Commercial Scale Synthesis of High Surface Area Macroporous Silica for Bioanalytical Chromatography".
For a representative manuscript, please see:
New Macroporous Silica Microparticles Derivatized for Enhanced Lectin Affinity Enrichment of Glycoproteins
ARTICLE LINK Mann, B. F.; Mann, A. K. P.; Skrabalak, S. E.; Novotny, M. V. "New Macroporous Silica Microparticles Derivatized for Enhanced Lectin Affinity Enrichment of Glycoproteins" Analytical Chemistry, 2013, 85, 1905-1912.